Enterprise networks are complex and often span multiple locations with a mix of cloud and on-premise resources. Securing these networks is critical to protect sensitive business data and maintain operational integrity. 

Here are the key security considerations for enterprise networks:

1. Network Segmentation and Access Control: Segmentation: Divide the network into smaller, manageable segments to isolate critical data and systems from general network traffic. This can limit the spread of malicious activities in case of a breach. Access Control: Implement strict access controls using the principle of least privilege, where users and devices are granted the minimum level of access necessary for their functions. This includes managing user permissions and using role-based access control systems.
2. Data Encryption: At Rest and In Transit: Encrypt sensitive data both at rest and in transit to protect it from unauthorized access. Use strong encryption protocols such as AES for data at rest and TLS for data in transit.
3. Intrusion Detection and Prevention Systems (IDPS): Deploy intrusion detection systems (IDS) and intrusion prevention systems (IPS) to monitor network traffic for suspicious activity and potential threats. These systems can alert administrators to anomalous actions and block malicious traffic automatically.
4. Regular Security Audits and Penetration Testing: Conduct regular security audits to assess the effectiveness of your security measures. Complement this with penetration testing from external experts who simulate cyber attacks to identify vulnerabilities.
5. Advanced Threat Protection: Implement advanced threat protection solutions that use machine learning and behavior analysis to detect and respond to unusual activity that may indicate a sophisticated cyber attack.
6. Endpoint Security: Ensure that all endpoint devices connecting to the network, including mobile devices and remote workstations, are secured. This includes antivirus/anti-malware software, personal firewalls, and regular patch management.
7. Secure Configuration and Patch Management: Maintain a secure configuration for all network devices and systems. Regularly update and patch operating systems, applications, and firmware to protect against vulnerabilities.
8. Firewalls and Virtual Private Networks (VPNs): Use firewalls to block unauthorized access to the network and VPNs to secure remote connections. Ensure these are properly configured and updated to defend against new threats.
9. Employee Training and Awareness: Regularly train employees on cybersecurity best practices and the latest phishing tactics. Employee awareness can prevent many breaches that originate from human error.
10. Disaster Recovery and Business Continuity Planning: Develop and regularly update a comprehensive disaster recovery plan that includes procedures for data backup, system restoration, and maintaining operations during and after a security incident.
11. Regulatory Compliance: Ensure that network security practices comply with applicable regulations and standards such as GDPR, HIPAA, or PCI DSS, depending on your industry and location.
12. Zero Trust Architecture: Consider adopting a zero-trust security model where trust is never assumed, regardless of whether the network traffic originates inside or outside the network boundaries. This involves continuous verification of all users and devices.